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KMID : 0350519940470010495
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Journal of Catholic Medical College
1994 Volume.47 No. 1 p.495 ~ p.503
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Helicobacter pylori Infection and Gastric Carcinoma in Korean
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Abstract
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Gastric carcinoma is the most frequent malignant disease and the leading cause of cancer death in Korean. And the incidence of gastric carcinoma can change dramatically from place to place and from one generation to the next, it has been
hypothesized
that its incedence is determined largely by environmental rather than genetic factors.
One specific histologic type of gastric carcinoma. the so-called intestinal type, is particularly prone to the regional and temporal variations of an environmentally related malignant condition.
The recent identification of Helicobacter pylori in chronic inflammatory conditions of the stomach, however, has stimulated interest in its potential role in carcinogenesis. Helicobacter pylori has been linked to chronic atrophic gastritis, an
established precursor of intestinal type of gastric carcinoma.
We designed a study to estimate the prevalence of Helicobacter pylori in 41 patients of intestinal type of gastric carcinoma and in 88 age and sex matched control persons by histologic examination of stomach in Wathin-Starry staining.
@ES The results were as follow;
1. In gastric carcinoma. 85.37% of 41 patients of intestinal type carcinoma, and 59.52% of 42 patients of diffuse type carcinoma were positive for Helicobacter pylori. In control group, 27.27% of 88 person was positive for Helicobacter pylori.
2. To compare to control group, intestinal type of gastric carcinoma was more high incidence of Helicobacter pylori infection to than that of diffuse type of gastric carcinoma.
These findings suggest that Helicobacter pylori infection of stomach may be related to the gastric carcinoma in Korean. And Helicobacter pylori is more frequently found in the intestinal type of gastric carcinoma than diffuse type of gastric
carcinoma.
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